منابع مشابه
BBB building
Sometimes you can get to your destination just by following the crowd. Baker et al. report that photoreceptor proteins lacking targeting sequences end up in the right place thanks to their more abundant, and more goal-oriented, fellow travelers. Rod and cone cells are divided into four compartments: a synaptic terminal, a nuclear region, an inner segment for protein and lipid synthesis, and an ...
متن کاملHypothalamic Leptin Resistance: From BBB to BBSome.
In 1969, Douglas Coleman joined the bodies of an obese and a normal mouse by a procedure called parabiosis. Days later, the normal mouse starved. Something had taken away its desire to eat [1]. It was not until almost 25 years later that the true nature of what Coleman then called "satiety factor" was revealed. In 1994, Jeffrey Friedman identified the adipocytic hormone leptin [2,3] and it was ...
متن کاملPlatelets Contribute to BBB Disruption Induced by HIV and Alcohol
The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol us...
متن کاملFormation and maintenance of the BBB
The central nervous system (CNS) is vascularized by a dense capillary network that is critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from the neural tissue. These blood vessels contain a series of properties, termed the blood-brain barrier (BBB), which distinguishes them from vasculature in other tissues, enabling CNS vessels to stringently regulate the ...
متن کاملA novel hypothesis of blood-brain barrier (BBB) development and in vitro BBB model: neural stem cell is the driver of BBB formation and maintenance
There is an ongoing effort to develop in vitro models for the blood-brain barrier (BBB) research and the central nervous system (CNS) drug screening. But the phenotypes of the existing in vitro models are still very remote from those found in vivo. The trouble in establishing in vitro BBB models comes from the unclear mechanism of the BBB formation and maintenance. The astrocytes have been foun...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2018
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2018.11.039